OasisLMS

Abstract: Eli Lilly and Company are investing $4.5 billion to create the Lilly Medicine Foundry, a new center for advanced manufacturing and drug development, combining research and manufacturing in a single location. The Medicine Foundry will be located in Indiana's LEAP Research and Innovation District in Lebanon, Indiana and will expand the company's investment there to more than $13 billion.

Multiple new facilities are planned for the manufacture of Petides (short chains of amino acids that are involved in many physiological processes and biochemical functions), Oligonucleotides (short chains of nucleotides that can be made of DNA or RNA) and Small Molecules (molecules with a molecular weight of < 900 Da) with a Central Utility Building (CUB) and an extensive array of pipe and utility racks to support all of the manufacturing facilities. The facilities are being constructed on pads of structural fill approximately 10-ft to 15-ft above the natural ground surface. Native soils are generally up to 35 feet of soft to stiff alluvial soil with stiff to very hard glacial deposits underlying the site. Column loads for manufacturing facilities typically ranged from 400 to 1000 tons with 4000 psf design bearing pressures for large floor areas in most of the facilities to accommodate the relatively heavy manufacturing equipment at each facility.

Project requirements include a maximum of 3/4 in total settlement of the structures. Given the size and overall weight of the structures and the large area loads of the manufacturing equipment within the structures, this specification became the primary design consideration for foundation support of the majority of the structures. The manufacturing facilities will be supported on a combination of Augered-Cast-in-Place (ACIP) piles under building columns and augered, Rigid Inclusions (RIs) under the floors. The CUB facility will be supported by a range of augered, Rigid Inclusions under columns and floors depending on the required support across the facility. To date, approximately 6, 500 ACIP piles and 4, 700 RIs have been installed to support these facilities.

This paper addresses the design and construction of the referenced ACIP piles and RIs with particular regard to the behavior of the foundation elements in the glacial till deposits underlying the site. Geotechnical site characterization information included logs of several borings and the results of cone penetration tests (CPT) performed to up to 100-ft below grade across the entire project site. The boring logs included visual classifications and Standard Penetration Test (SPT) results. Results of laboratory tests performed on collected samples were also included in the report. The results of several seismic CPTs were also provided. The shear wave velocity profile information indicated stiffnesses in the till deposits that were significantly greater than might be indicated by the CPT and boring data. The anticipated soil stiffnesses were verified by the pile and RI element performance testing program, allowing the project team to economize the foundation design for pile capacity, but more significantly for the estimation of overall structure settlement. Soil stiffness was additionally verified using the Automated Monitoring Equipment on board the pile and RI installation platforms (or Measurement While Drilling, MWD) to verify the stratigraphy encountered during foundation installation.

Mr. W. MORGAN NeSMITH; Mr. Jake McKean

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